Modeling cancer progression using human pluripotent stem cell-derived cells and organoids

Modeling cancer progression using human pluripotent stem cell-derived cells and organoids

Blog Article

Conventional cancer cell lines and animal models have been mainstays of cancer research.More recently, human pluripotent stem cells (hPSCs) and hPSC-derived organoid Placemats technologies, together with genome engineering approaches, have provided a complementary platform to model cancer progression.Here, we review the application of these technologies in cancer modeling with respect to the cell-of-origin, cancer propagation, and metastasis.

We further discuss the benefits and challenges accompanying the use of hPSC models for cancer research and discuss their broad applicability in drug discovery, biomarker identification, decoding molecular mechanisms, and the deconstruction of clonal and intra-tumoral heterogeneity.In summary, Washing Machine Interface Module hPSC-derived organoids provide powerful models to recapitulate the pathogenic states in cancer and to perform drug discovery.